Description
SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1).
SERPINE2 is a secreted glycoprotein which belongs to the serpin family.
SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA).
PAI-1 / GDN is also implicated in adipose tissue development.
It suggests that PAI-1 inhibitors serve in the control of atherothrombosis.
Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma